We are currently funded through the following collaborative, multidisciplinary projects:
NIH-NIA R01AG054180-02S1 Kazcorowski (PI) 2018-2019
Systems control of normal aging and Alzheimer’s disease
The objective of this project is to determine the functional and microstructural changes in response to aging and AD pathologies and as a function of genetic variation
Role: UF PI
NIH-NIA P50 AG047266 Golde (PD) 2015 – 2020
University of Florida – Mt. Sinai Medical Center AD Research Center
The goal of studies in Project I are to measure diffusion MRI, volumetric and free water imaging changes in animal models of neurodegeneration with and without inflammation and amyloidosis
Role: PI, Project I
NIH-NINDS UG3 NS106938 Wang (PI) 2018 – 2023
NIBA-TBI: Neuro-Imaging and biofluid-based biomarker assessments as translational pathophysiological outcome measures in TBI
The goal of these studies is to evaluate two complementary pathological mechanism-based TBI outcome measures – (i) biofluid biomarker assessment, and (ii) MRI-neuroimaging biomarker assessment.
Role: Co-I
NIH-NINDS R01NS075012 Vaillancourt/Li (PI) 2019-2024
Non-invasive markers of neurodegeneration in movement disorders
The objective is to determine the effects of various dystonia mutations on diffusion MRI metrics of free water and axon microstructure in mouse models
Role: Co-I
James and Esther King Award (8JK06) Hayward (PI) 2018-2020
The role of gut-microbiome axis in cardiovascular disease following prenatal exposure to nicotine
The goal is to determine the neural response to short chain fatty acids present in gut microbiota in rats prenatally exposed to nicotine.
Role: Co-I
NIH-NINDS R01 NS103094 Candelario-Jalil (PI) 2018-2023
Neurovascular protection by adropin in ischemic stroke
The project applies diffusion, structural and functional imaging of rats with experimentally induced ischemic stroke to determine the neuroprotective mechanisms of adropin
Role: Co-I
NIH-NIDA R03 DA042971 Febo (PI) 2017-2019
Preclinical imaging of adolescent cannabidiol on brain structure and functional connectivity
Cannabidiol (CBD) will be administered during adolescence to control rats and animals with gestational exposure to valproic acid. The goal is to determine the behavioral, neurobiological and functional changes with CBD and its potential preclinical use for treating autism like behaviors in rats.
Role: PI
NSF DMR-1157490 Long (UF PI) 2018-2023
National High Field Magnet Laboratory
Administrative and facilities support for Advanced Magnetic Resonance Imaging and Spectroscopy facility at University of Florida.
Role: Co-I
NIH-NINDS R56 NS103094 Candelario-Jalil (PI) 2017-2018
Neurovascular protection by adropin in ischemic stroke
The project applies diffusion, structural and functional imaging of rats with experimentally induced ischemic stroke to determine the neuroprotective mechanisms of adropin
Role: Co-I
NIH-NIDA R01 DA042530 Bruijnzeel (PI) 2016-2019
Tobacco: relationship between reduced nicotine content and reinforcement in rats
The project uses a combination of intracranial self-stimulation to measure brain reward thresholds and self-administration to measure nicotine reinforcement to assess the effect of nicotine content in cigarettes on brain reward function.
Role: Co-I