Amyloid, aging and functional brain networks
Febo M, Mahar R, Rodriguez NA, Pompilus M, Buraima J, Pinto AM, Grudny M, Bruijnzeel AW, Merritt M. Age-related differences in affective behaviors in mice: possible role of prefrontal cortical-hippocampal functional connectivity and metabolic profiles. Frontiers in Aging Neuroscience, 2024, accepted.
Murdy TJ, Dunn AR, Singh S, Telpoukhovskaia MA, Zheng S, White JK, Kahn I, Febo M, Kaczorowski CC. Heritable brain microstructural features may confer brain reserve to Alzheimer’s disease. Frontiers in Behavioral Neuroscience, 2023, 16:1033975. [PMID: 36703722]
Gaynor LS, Ravi M, Zequiera S, Hampton AM, Pyon W, Smith S, Colon-Perez LM, Pompilus M, Bizon JL, Maurer AP, Febo M, Burke SN. Touchscreen-based cognitive training alters functional connectivity patterns in aged but not young male rats. eNeuro, 2023, 10(2):ENEURO.0329-22.2023. Research
Kotlarz P, Nino JC, Febo M. Connectomic analysis of Alzheimer’s disease using percolation theory. Network Neuroscience, 2022, 6(1): 213-233.
Cruz-Almeida Y, Coombes S, Febo M. Pain differences in neurite orientation dispersion and density imaging measures among community-dwelling older adults. Experimental Gerontology, 154: 111520. [PMID: 34418483]
Pompilus M, Colon-Perez LM, Grudny, MM, Febo M. Contextual experience modifies functional connectome indices of topological strength and efficiency. Scientific Reports, 2020, 10(1):19843. [PMID: 33199790]
Barter J, Kumar A, Rani A, Colon-Perez LM, Febo M, Foster TC. Differential effect of lipopolysaccharide treatment and aging on hippocampal function and biomarkers of hippocampal senescence. Molecular Neurobiology, 2020, 57(10):4045-4059.[PMID:32651758]
Nephew BC, Febo M, Cali R, Workman K, Payne L, Moore C, King J, Lacreuse A. Robustness of sex-differences in functional connectivity over time in middle-aged marmosets. Scientific Reports, 2020, 10(1):16647.[PMID:33024242]
Febo M, Rani A, Yegla B, Kumar A, Wolff CA, Esser K, Foster TC. Longitudinal characterization and biomarkers of age and sex differences in the decline of spatial memory. Frontiers in Aging Neuroscience, 2020, 12:34. [PMID:32153384]
Colon-Perez LM, Ibanez KR, Suarez MK, Torroella K, Acuna K, Ofori E, Levites Y, Vaillancourt DE, Golde TE, Chakrabarty P, Febo M. Neurite orientation dispersion and density imaging reveals white matter and hippocampal microstructure changes produced by interleukin-6 in the TgCRND8 mouse model of amyloidosis. Neuroimage, 2019, 202:116138. [PMID: 31472250]
Febo M, Perez PD, Ceballos-Diaz C, Colon-Perez LM, Ofori E, Golde TE, Vaillancourt DE, Chakrabarty P. Diffusion MRI-derived free water measures neurodegenerative patterns induced by interferon-ɣ. Brain Structure and Function, 2020, 225(1):427-439. [PMID: 3184407]
LaClair M, Febo M, Nephew BC, Gervais NJ, Poirier G, Workman K, Payne L, Silva A, Moore MC, King JA, Lacreuse A. Sex differences in cognitive flexibility and resting brain networks in middle-aged marmosets. eNeuro, 2019, 6(4):ENEURO.0154-19.2019. [PMID: 31262949]
Colon-Perez LM, Turner SM, Lubke KN, Febo M, Burke SN. Multi-scale imaging reveals aberrant connectome organization and elevated dorsal striatal Arc expression in advanced age. eNeuro, 2019, 6(6):ENEURO.0047-19.2019. [PMID: 31826916]
Febo M, Foster TC. Preclinical magnetic resonance imaging and spectroscopy studies of memory, aging, and cognitive decline. Frontiers in Aging Neuroscience, 2016, 8:158. [PMID: 27468264]
Sahara N, Perez PD, Ren Y, Lewis J, Febo M. Age-related decline in white matter integrity in a mouse model of tauopathy: an in vivo diffusion tensor magnetic resonance imaging study. Neurobiology of Aging, 2014 Jun; 35(6):1364-1374. [PMID: 24411290]
Perez PD, Hall G, Kimura T, Ren Y, Lewis J, Febo M, Sahara N. In vivo functional brain mapping in a conditional mouse model of human tauopathy (tauP301L) reveals reduced neural activity in memory formation structures, Molecular Neurodegeneration, 2013; 8:9. [PMID: 23379588]
Preclinical imaging in rodent models of traumatic brain injury
Criado-Marrero M, Ravi S, Bhaskar E, Barroso D, Pizzi MA, Williams L, Willington CL, Febo M, Abisambra JF. Age dictates brain functional connectivity and axonal integrity following repetitive mild traumatic injuries. Neuroimage, 2024, in review
Kommireddy RS, Mehra S, Pompilus M, Arja RD, Zhu T, Yang Z, Fu Y, Kobeissy F, Wang KK, Febo M. Functional connectivity, tissue microstructure and T2 at 11.1 Tesla distinguishes neuroadaptive differences in two traumatic brain injury models in rats: A translational outcomes project in neurotrauma (TOP-NT) UG3 phase study. Neurotrauma Reports, 2024, in review
Wanner IB, McCabe JT, Harris NG, Huie R, Koehler RC, Ferguson AR, Febo M, van Meter TE, Korotcov A, Burns M, McMann-Chapman, Radabaugh HL, Wang K, Kobeissy F, Zhou J, Allende-Labastida J, Lex M, Apiliogullari S, Awwad H, Bellgowan P, the TOP-NT Consortium Investigators. Common data elements and data harmonization in preclinical TBI narrow translational gaps: a translational outcomes project in neurotrauma (TOP-NT) study. Journal of Neurotrauma, 2024, in review
Ravi S, Criado-Marrero M, Barroso D, Braga I, Bolen M, Rubinovich U, Hery G, Grudny M, Koren J, Prokop S, Febo M, and Jose Abisambra. Fixed time point analysis reveals repetitive mild traumatic brain injury effects on resting state functional magnetic resonance imaging connectivity and neuro-spatial protein profiles. Journal of Neurotrauma, 2023, 40(19-20): 2037-2049 [PMID: 37051703].
Yang Z, Zhu T, Pompilus M, Zhu J, Arjona K, Arja RD, Grudny MM, Plant HD, Bose P, Wang KK, Febo M. Brain Communications, 2021, 3(4): fcab244. [PMID: 34729482]
Yang Z, Wang P, Morgan D, Bruijnzeel AW, Lin D, Pan J, Lin F, Strang KH, Selig TM, Perez PD, Febo M, Chang B, Rubenstein R, Wang KK. Temporal MRI characterization, neurobiochemical and neurobehavioral changes in a mouse repetitive concussive head injury model. Scientific Reports, 2015; 5: 11178. [PMID: 26058556]
Functional brain mapping of the effects of drugs of abuse
Martyniuk CJ, Pompilus M, Duncan A, Febo M. The effects of acute and repeated methylenedioxypyrovalerone (MDPV) administration on striatal transcriptome networks in male long evans rats. Neuroscience Letters, 2019, 712:134499. [PMID: 31536752]
Orsini CA, Colon-Perez LM, Heshmati SC, Setlow B, Febo M. Functional connectivity of chronic cocaine use relative to a baseline reveals progressive neuroadaptations in neocortical, striatal and limbic networks. ENeuro, 2018, 5(4) ENEURO.0081-18.2018 [PMID: 30073194]
Colon-Perez LM, Pino JA, Saha K, Pompilus M, Kaplitz S, Choudhury N, Jagnarine DA, Geste JR, Levin BA, Wilks IJ, Setlow B, Bruijnzeel AW, Khoshbouei H, Torres GE, Febo M. Functional connectivity, behavioral, dopaminergic alterations 24 hours following acute exposure to synthetic bath salt drug methylenedioxypyrovalerone. Neuropharmacology, 2018, 137:178-193. Research [PMID: 29729891]
Perez PD, Hall G, Zubcevic J, Febo M. Cocaine differentially affects synaptic activity in memory and midbrain areas of female and male rats: an in vivo MEMRI study. Brain Imaging and Behavior, 2018, 12(1):201-216 [PMID: 28236167]
Febo M, Blum K, Badgaiyan RD, Perez PD, Colon-Perez LM, Thanos PK, Ferris CF, Kulkarni P, Giordano J, Baron D, Gold MS. Enhanced functional connectivity and volume between cognitive and reward centers in naïve rodent brain produced by pro-dopaminergic agent KB220Z. PLoS One, 2017, 12(4): e0174774. [PMID: 28445527].
Colon-Perez LM, Tran K, Thompson K, Pace MC, Blum K, Goldberger BA, Gold MS, Bruijnzeel AW, Setlow B, Febo M. The psychoactive designer drug and bath salt constituent MDPV causes widespread disruption of brain functional connectivity. Neuropsychopharmacology, 2016, 41(9):2352-65. [PMID: 26997298]
Reed MD, Hildebrand DG, Santangelo G, Moffa A, Pira AS, Rycyna L, Radic M, Price K, Archbold J, McConnell K, Girard L, Morin K, Tang A, Febo M, Stellar JR. Assessing contributions of nucleus accumbens shell subregions to reward-seeking behavior. Drug and Alcohol Dependence, 2015 Aug; 153, 369-373. [PMID: 26048642]
Caffrey MK, Febo M. Cocaine-associated odor cue re-exposure increases blood oxygenation level dependent signal in memory and reward regions of the maternal rat brain. Drug and Alcohol Dependence, 2014 Jan; 134: 67-177. [PMID: 24183499]
Johnson TR, Smerkers B, Moulder JK, Stellar JR, Febo M. Neural processing of a cocaine-associated odor cue revealed by functional magnetic resonance imaging in awake rats. Neuroscience letters, 2013; 534:160-5. [PMID: 23262077]
Nephew BC, Caffrey MK, Felix-Ortiz AC, Febo M. Cocaine sensitization increases kyphosis and modulates neural activity in adult nulliparous rats. Brain Sciences, 2012; 2(4): 667-683. [PMID: 24371520]
Febo, M, Pira, AS. Increased BOLD activation to predator stressor in ventral hippocampus and midbrain of amphetamine-sensitized maternal rats Brain Research, 2011; 1382:118-127. [PMID: 21134359]
Febo, M. Prefrontal cell firing in male rats during approach towards sexually receptive female: interactions with cocaine. Synapse, 2011; 65: 271-277. [PMID: 20687107]
Nephew BC, Febo M. Effect of cocaine sensitization prior to pregnancy on maternal care and aggression in the rat. Psychopharmacology, 2010 Mar; 209(1):127-135. [PMID: 20101390]